According to the Web Md website: Proton pump inhibitors work best when they are taken 30 minutes before your first meal of the day.
http://www.webmd.com/heartburn-gerd/proton-pump-inhibitors-for-gastroesophageal-reflux-disease-gerd
http://www.webmd.com/heartburn-gerd/proton-pump-inhibitors-for-gastroesophageal-reflux-disease-gerd
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